Ebola, Big Data, Childhood Cancers and Medicines Safety Feature in New IMI Call

Innovative Medicines InitiativeThe Innovative Medicines Initiative (IMI) has launched two Calls for proposals that will advance medicines development in critical areas such as Ebola, childhood cancers, neurological disorders, and eye disease. The Calls will also add to IMI's growing programme on Big Data for Better Outcomes.

Ebola - The recent Ebola outbreak in western Africa infected over 28 000 people and killed over 11 000, starkly highlighting the urgent need for new vaccines, treatments and diagnostic tests for this devastating disease. IMI and others responded to this emergency by rapidly launching Ebola research programmes. However, further efforts are needed to ensure the world is equipped to stop future outbreaks in their tracks. With this in mind, IMI is launching a €70 million open Call for proposals that invites consortia to submit proposals covering diverse aspects of Ebola research, including the development of vaccines, diagnostic tests, and treatments. The resulting projects should be able to capture emerging scientific advances and turn them into healthcare interventions that will increase our readiness to react to future outbreaks of Ebola or related diseases.

In parallel, IMI is launching a standard Call for proposals with seven topics, including two on big data.

Big data for better outcomes - In addition to a topic to coordinate and support the entire big data programme, the Call includes a topic that aims to improve clinical outcomes for people with heart disease through better access to, and use of data.

Childhood cancers - Today, 20% of childhood cancers remain incurable and survivors of childhood cancers often experience long-term side effects. This topic will deliver a platform of research tools to facilitate the identification of potential drugs for childhood cancers.

Alzheimer's and Parkinson's diseases - The focus of this topic is on how protein tangles, which are hallmarks of both diseases, spread throughout the brain. The project results will therefore increase our chance of identifying new targets for drugs.

Chronic pain - Neuropathic pain affects 6-8% of the population and is extremely hard to treat. This topic focuses on improving our understanding of the underlying causes of neuropathic pain, something that will aid in the development of new treatments.

Eye diseases - There are currently no effective treatments for dry age-related macular degeneration (AMD), and it is one of the leading causes of blindness worldwide. This topic aims to develop new and better measures of patients' disease status that could be used when testing new drugs in clinical trials.

Medicines safety - This topic aims to advance the use of imaging in assessments of medicines safety. Among other things, this would improve medicines safety, add to our understanding of why medicines sometimes cause toxicity, and reduce the use of animals in research.

Pierre Meulien, IMI Executive Director commented: "These Calls for proposals demonstrate the added value of IMI. Excellent science exists in all of these research areas, but only by bringing together experts from industry, academia, small biotechs, patient groups, and others can we hope to translate world-class science into improved health for patients."

The Ebola Call (IMI 2 - Call 8) has a total budget of €70 million from IMI that will be available from the first cut-off date of the two year open application period. The other Call (IMI 2 - Call 7) has a budget from IMI of €46.8 million; this will go to eligible universities, small companies, and patient organisations, etc. This will be matched by €46.8 million from the EFPIA companies in the projects; these companies do not receive any money from IMI but contribute largely 'in kind', e.g. by donating their researchers' time, or access to equipment and resources.

IMI 2 - Call 7
Topics on safety, Alzheimer's/Parkinson's diseases, pain, eye diseases, childhood cancers, big data
Deadline for submitting proposals: 17 March 2016
Call documents and details of how to apply: http://www.imi.europa.eu/content/stage-1-18

IMI 2 - Call 8
Ebola and related diseases This Call for proposals will remain open for two years with the following cut-off dates for the submission of proposals: 16 March 2016, 15 September 2016, 16 March 2017, 14 September 2017, 15 March 2018.
Call documents and details of how to apply: http://www.imi.europa.eu/content/imi-2-call-8

About the Innovative Medicines Initiative
The Innovative Medicines Initiative (IMI) is working to improve health by speeding up the development of, and patient access to, innovative medicines, particularly in areas where there is an unmet medical or social need. It does this by facilitating collaboration between the key players involved in healthcare research, including universities, the pharmaceutical and other industries, small and medium-sized enterprises (SMEs), patient organisations, and medicines regulators.

IMI is a partnership between the European Union and the European pharmaceutical industry, represented by the European Federation of Pharmaceutical Industries and Associations (EFPIA). Through the IMI 2 programme, IMI has a budget of €3.3 billion for the period 2014-2024. Half of this comes from the EU's research and innovation programme, Horizon 2020. The other half comes from large companies, mostly from the pharmaceutical sector; these do not receive any EU funding, but contribute to the projects 'in kind', for example by donating their researchers' time or providing access to research facilities or resources.

Most Popular Now

Unlocking the 10 Year Health Plan

The government's plan for the NHS is a huge document. Jane Stephenson, chief executive of SPARK TSL, argues the key to unlocking its digital ambitions is to consider what it...

Alcidion Grows Top Talent in the UK, wit…

Alcidion has today announced the addition of three new appointments to their UK-based team, with one internal promotion and two external recruits. Dr Paul Deffley has been announced as the...

AI can Find Cancer Pathologists Miss

Men assessed as healthy after a pathologist analyses their tissue sample may still have an early form of prostate cancer. Using AI, researchers at Uppsala University have been able to...

New Training Year Starts at Siemens Heal…

In September, 197 school graduates will start their vocational training or dual studies in Germany at Siemens Healthineers. 117 apprentices and 80 dual students will begin their careers at Siemens...

AI, Full Automation could Expand Artific…

Automated insulin delivery (AID) systems such as the UVA Health-developed artificial pancreas could help more type 1 diabetes patients if the devices become fully automated, according to a new review...

How AI could Speed the Development of RN…

Using artificial intelligence (AI), MIT researchers have come up with a new way to design nanoparticles that can more efficiently deliver RNA vaccines and other types of RNA therapies. After training...

MIT Researchers Use Generative AI to Des…

With help from artificial intelligence, MIT researchers have designed novel antibiotics that can combat two hard-to-treat infections: drug-resistant Neisseria gonorrhoeae and multi-drug-resistant Staphylococcus aureus (MRSA). Using generative AI algorithms, the research...

AI Hybrid Strategy Improves Mammogram In…

A hybrid reading strategy for screening mammography, developed by Dutch researchers and deployed retrospectively to more than 40,000 exams, reduced radiologist workload by 38% without changing recall or cancer detection...

Penn Developed AI Tools and Datasets Hel…

Doctors treating kidney disease have long depended on trial-and-error to find the best therapies for individual patients. Now, new artificial intelligence (AI) tools developed by researchers in the Perelman School...

Are You Eligible for a Clinical Trial? C…

A new study in the academic journal Machine Learning: Health discovers that ChatGPT can accelerate patient screening for clinical trials, showing promise in reducing delays and improving trial success rates. Researchers...

Global Study Reveals How Patients View M…

How physicians feel about artificial intelligence (AI) in medicine has been studied many times. But what do patients think? A team led by researchers at the Technical University of Munich...

New AI Tool Addresses Accuracy and Fairn…

A team of researchers at the Icahn School of Medicine at Mount Sinai has developed a new method to identify and reduce biases in datasets used to train machine-learning algorithms...