in silico Clinical Trials: How Computer Simulation will Transform the Biomedical Industry

The term 'in silico clinical trials' refers to: "The use of individualised computer simulation in the development or regulatory evaluation of a medicinal product, medical device, or medical intervention." While computer simulation is widely used for the development and de-risking of a number of 'mission-critical' products such as civil aircraft, nuclear power plants, etc, biomedical product development and assessment is still predominantly founded on experimental rather than computer-simulated approaches. The need for long and complex experiments in vitro, on animals, and then on patients during clinical trials pushes development costs to unsustainable levels, stifling innovation, and driving the cost of healthcare provision to unprecedented levels.

The Avicenna Action, funded by the European Commission, has engaged 525 experts from 35 countries, including 22 of the 28 members of the European Union, in an 18-month consensus process, to produce this research and technological development roadmap.

This document provides an overview of how biomedical products are developed today, where in silico clinical trials technologies are already used, and where else they could be used. From the identification of the barriers that prevent wider adoption, we derived a detailed list of research and technological challenges that require pre-competitive funding to be overcome.

Download: in silico Clinical Trials: How Computer Simulation will Transform the Biomedical Industry (.pdf, 5.500 KB).

Download from eHealthNews.eu: in silico Clinical Trials: How Computer Simulation will Transform the Biomedical Industry (.pdf, 5.500 KB).

Most Popular Now

Northern Lincolnshire and Goole NHS Foun…

Northern Lincolnshire and Goole NHS Foundation Trust (NLAG) has launched new NHS App features to transform the way patients access and manage their appointments within the NHS. The programme, known...

Orion Health Strengthens French Business…

Orion Health is strengthening its presence in France with the appointment of digital health industry heavyweight, Tristan Debove, to lead its operations. Tristan Debove has more than 25 years of experience...

Genomics England Deploys Sectra Imaging …

Genomics England has completed installation of an enterprise imaging system that will help to support a world-pioneering initiative for cancer research. The programme is linking whole genome sequencing, pathology and...

AI Approach may Help Detect Alzheimer's …

Although investigators have made strides in detecting signs of Alzheimer's disease using high-quality brain imaging tests collected as part of research studies, a team at Massachusetts General Hospital (MGH) recently...

AI Predicts Cancer Patient Survival by R…

A team of researchers from the University of British Columbia and BC Cancer have developed an artificial intelligence (AI) model that predicts cancer patient survival more accurately and with more...

Virtual Reality Games can be Used as a T…

Virtual reality gamers (VR game) who finished it faster than their fellow gamers also have higher levels of general intelligence and processing capacity. This was the result of a study...

Will Future Computers Run on Human Brain…

A "biocomputer" powered by human brain cells could be developed within our lifetime, according to Johns Hopkins University researchers who expect such technology to exponentially expand the capabilities of modern...

Detecting Anaemia Earlier in Children Us…

Researchers at UCL and University of Ghana have successfully predicted whether children have anaemia using only a set of smartphone images. The study, published in PLOS ONE, brought together researchers and...

AI can Help Optimize CT Scan X-Ray Radia…

Computed tomography (CT) is one of the most powerful and well-established diagnostic tools available to modern medicine. An increasing number of people have been opting for CT scans, raising concerns...

Study Reveals Smartphone Spyware Apps ar…

Smartphone spyware apps that allow people to spy on each other are not only hard to notice and detect, they also will easily leak the sensitive personal information they...

Orion Health Appoints Mark Hindle as Vic…

Orion Health has appointed Mark Hindle as its new vice president for the UK and Ireland. Mark has joined the leading supplier of digital tools to improve healthcare experience from...