in silico Clinical Trials: How Computer Simulation will Transform the Biomedical Industry

The term 'in silico clinical trials' refers to: "The use of individualised computer simulation in the development or regulatory evaluation of a medicinal product, medical device, or medical intervention." While computer simulation is widely used for the development and de-risking of a number of 'mission-critical' products such as civil aircraft, nuclear power plants, etc, biomedical product development and assessment is still predominantly founded on experimental rather than computer-simulated approaches. The need for long and complex experiments in vitro, on animals, and then on patients during clinical trials pushes development costs to unsustainable levels, stifling innovation, and driving the cost of healthcare provision to unprecedented levels.

The Avicenna Action, funded by the European Commission, has engaged 525 experts from 35 countries, including 22 of the 28 members of the European Union, in an 18-month consensus process, to produce this research and technological development roadmap.

This document provides an overview of how biomedical products are developed today, where in silico clinical trials technologies are already used, and where else they could be used. From the identification of the barriers that prevent wider adoption, we derived a detailed list of research and technological challenges that require pre-competitive funding to be overcome.

Download: in silico Clinical Trials: How Computer Simulation will Transform the Biomedical Industry (.pdf, 5.500 KB).

Download from eHealthNews.eu: in silico Clinical Trials: How Computer Simulation will Transform the Biomedical Industry (.pdf, 5.500 KB).

Most Popular Now

AI Harnesses Tumor Genetics to Predict T…

In a groundbreaking study published on January 18, 2024, in Cancer Discovery, scientists at University of California San Diego School of Medicine leveraged a machine learning algorithm to tackle one...

Northern Care Alliance Deploys Digital P…

The trust's Oldham laboratory has completed technical go-live, with its Salford site also set to follow. Collectively the laboratories provide a wide range of general and specialist pathology services that...

American College of Radiology Releases J…

The American College of Radiology® (ACR®), working in close collaboration with four other radiology societies from around the world, have issued a joint statement on the development and use of...

Nine Tasks and One Big Challenge for Sha…

Opinion Article by Mark Hindle, vice president EMEA, Orion Health,. It's going to be a busy year in the shared care records space. NHS leaders, ShCRs and their suppliers are going...

Autonomous Synthesis Robot Uses AI to Sp…

Chemists of the University of Amsterdam (UvA) have developed an autonomous chemical synthesis robot with an integrated AI-driven machine learning unit. Dubbed 'RoboChem', the benchtop device can outperform a human...

AI in Personalized Cancer Medicine: New …

The application of AI in precision oncology has so far been largely confined to the development of new drugs and had only limited impact on the personalisation of therapies. New...

Paper Calls for Patient-First Regulation…

Ever wonder if the latest and greatest artificial intelligence (AI) tool you read about in the morning paper is going to save your life? A new study published in JAMA...

AI can Predict Brain Cancer Patients…

Artificial Intelligence (AI) can predict whether adult patients with brain cancer will survive more than eight months after receiving radiotherapy treatment. The use of the AI to successfully predict patient outcomes...

Max Planck Institute for Informatics and…

The Max Planck Institute for Informatics and Google deepen their strategic research partnership. With additional financial support from the U.S. IT company, the "Saarbrücken Research Center for Visual Computing, Interaction...

JMIR Medical Informatics Invites Submiss…

JMIR Publications has announced a new section titled, "AI Language Models in Health Care" in JMIR Medical Informatics. This leading peer-reviewed journal is indexed in PubMed and has a unique...

DMEA nova Award: Wanted - Visionary Solu…

9 - 11 April 2024, Berlin, Germany. The DMEA nova Award is being presented at DMEA 2024 for the first time. The award honours a digital health startup for an outstanding...

Could ChatGPT Help or Hurt Scientific Re…

Since its introduction to the public in November 2022, ChatGPT, an artificial intelligence system, has substantially grown in use, creating written stories, graphics, art and more with just a short...