"We are hoping that these findings could be used to develop an ‘opportunistic screening’ tool to repurpose existing MRI and CT scans taken at the hospital to find patients with high-risk body composition who may be flying under the radar and could benefit from targeted diabetes and cardiovascular disease prevention," said co-senior author Vineet K. Raghu, PhD, a computational scientist with the Mass General Brigham Heart and Vascular Institute.
Raghu and colleagues conducted a prospective cohort study using data from the U.K. Biobank. The researchers used whole-body MRIs from more than 33,000 adults with no prior history of diabetes or cardiovascular events who were followed for a median of 4.2 years.
The team found that in both men and women, AI-derived visceral adipose tissue volume (fat surrounding the abdominal organs) and fat deposits in muscle were strongly associated with diabetes and cardiovascular disease risk beyond standard measures of obesity like BMI and waist circumference. In men only, lower skeletal muscle volume was strongly associated with risk.
The authors note that future studies are needed to determine if their findings are generalizable and if AI can reliably measure these body composition metrics from routine scans. With further validation, an AI-driven approach could help leverage routine imaging to identify patients at high risk.
Jung M, Reisert M, Rieder H, Rospleszcz S, Lu MT, Bamberg F, Raghu VK, Weiss J.
Association Between Body Composition and Cardiometabolic Outcomes: A Prospective Cohort Study.
Ann Intern Med. 2025 Sep 30. doi: 10.7326/ANNALS-24-01863