Building Trust in Artificial Intelligence for Healthcare: Lessons from Clinical Oncology

A new review, published in the peer-reviewed journal AI in Precision Oncology, explores the multifaceted reasons behind the skepticism surrounding artificial intelligence (AI) technologies in healthcare and advocates for approaches to build confidence in AI applications.

David Waterhouse, MD, MPH, from Chief Innovation Officer of Oncology Hematology Care, and an Editorial Board Member of AI in Precision Oncology, Terence Cooney-Waterhouse, from VandHus LLC, and coauthors, emphasize the importance of trust as a prerequisite for successful integration of AI into clinical practice.

Despite recognizing the potential benefits of AI, patients express significant concerns about data privacy, algorithmic bias, and the lack of transparency in AI decision-making processes. Physicians tend to be driven by doubts about the clinical validation and interpretability of AI systems.

To build confidence in AI applications, the authors advocate "for the implementation of robust data governance frameworks, enhanced transparency, and active involvement of stakeholders in AI development." They underscore "the necessity of addressing ethical implications and ensuring equitable access to AI-driven innovations."

"Integrating artificial intelligence into oncology care is much like introducing a new colleague to an established clinical team. Just as we wouldn't immediately trust a new team member with critical decisions without proper vetting, training, and transparency, we must approach AI implementation with similar rigor and care. Trust isn't granted - it's earned through demonstrated reliability, transparent processes, and consistent results. By prioritizing ethical frameworks, clinical validation, and patient-centered approaches, we can transform AI from a misunderstood technological tool into a trusted ally in the fight against cancer," says Douglas Flora, MD, Editor-in-Chief of AI in Precision Oncology.

Cooney-Waterhouse T, Ou W, Mukherji S, Frytak J, Saha P, Waterhouse D.
Bridging the Trust Gap in Artificial Intelligence for Health care: Lessons from Clinical Oncology.
AI in Precision Oncology, 2025. doi: 10.1089/aipo.2025.0001

Most Popular Now

AI Catches One-Third of Interval Breast …

An AI algorithm for breast cancer screening has potential to enhance the performance of digital breast tomosynthesis (DBT), reducing interval cancers by up to one-third, according to a study published...

Great plan: Now We need to Get Real abou…

The government's big plan for the 10 Year Health Plan for the NHS laid out a big role for delivery. However, the Highland Marketing advisory board felt the missing implementation...

Researchers Create 'Virtual Scienti…

There may be a new artificial intelligence-driven tool to turbocharge scientific discovery: virtual labs. Modeled after a well-established Stanford School of Medicine research group, the virtual lab is complete with an...

From WebMD to AI Chatbots: How Innovatio…

A new research article published in the Journal of Participatory Medicine unveils how successive waves of digital technology innovation have empowered patients, fostering a more collaborative and responsive health care...

New AI Tool Accelerates mRNA-Based Treat…

A new artificial intelligence (AI) model can improve the process of drug and vaccine discovery by predicting how efficiently specific mRNA sequences will produce proteins, both generally and in various...

Can Amazon Alexa or Google Home Help Det…

Computer scientists at the University of Rochester have developed an AI-powered, speech-based screening tool that can help people assess whether they are showing signs of Parkinson’s disease, the fastest growing...

AI also Assesses Dutch Mammograms Better…

AI is detecting tumors more often and earlier in the Dutch breast cancer screening program. Those tumors can then be treated at an earlier stage. This has been demonstrated by...

RSNA AI Challenge Models can Independent…

Algorithms submitted for an AI Challenge hosted by the Radiological Society of North America (RSNA) have shown excellent performance for detecting breast cancers on mammography images, increasing screening sensitivity while...

AI could Help Emergency Rooms Predict Ad…

Artificial intelligence (AI) can help emergency department (ED) teams better anticipate which patients will need hospital admission, hours earlier than is currently possible, according to a multi-hospital study by the...

Head-to-Head Against AI, Pharmacy Studen…

Students pursuing a Doctor of Pharmacy degree routinely take - and pass - rigorous exams to prove competency in several areas. Can ChatGPT accurately answer the same questions? A new...

NHS Active 10 Walking Tracker Users are …

Users of the NHS Active 10 app, designed to encourage people to become more active, immediately increased their amount of brisk and non-brisk walking upon using the app, according to...

The Human Touch of Doctors will Still be…

AI-based medicine will revolutionise care including for Alzheimer’s and diabetes, predicts a technology expert, but it must be accessible to all patients. Healing with Artificial Intelligence, written by technology expert Daniele...