Doctors often have patients perform simple motor tasks to assess movement disorders and rate the severity using guidelines such as the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The AI model provides a rapid assessment using the MDS-UPDRS guidelines, automatically generating computational metrics such as speed, amplitude, frequency, and period that are interpretable, standardized, repeatable, and consistent with medical guidebooks. It uses those attributes to classify the severity of tremors.
The finger-tapping task was performed by 250 global participants with Parkinson’s disease and the AI system's ratings were compared with those by three neurologists and three primary care physicians. While expert neurologists performed slightly better than the AI model, the AI model outperformed the primary care physicians with UPDRS certification.
The AI-based Parkinson's disease severity test generates computational metrics such as speed, amplitude, frequency, and period, and uses those attributes to classify the severity of tremors. (Photo provided)
"These findings could have huge implications for patients who have difficulty gaining access to neurologists, getting appointments, and traveling to the hospital," says Ehsan Hoque, an associate professor in Rochester's Department of Computer Science and co-director of the Rochester Human-Computer Interaction Laboratory. "It's an example of how AI is being gradually introduced into health care to serve people outside of the clinic and improve health equity and access."
The study was led by Md. Saiful Islam, a Google PhD fellow and a graduate student in computer science advised by Hoque. The team of computer scientists collaborated with several members of the Medical Center's Department of Neurology, including associate professor Jamie Adams; Ray Dorsey, the David M. Levy Professor of Neurology; and associate professor Ruth Schneider.
The researchers say their method can be applied to other motor tasks, which opens the door to evaluating other types of movement disorders such as ataxia and Huntington's disease. The new Parkinson's disease assessment is available online, though the researchers caution that it reflects an emerging technology and at this early stage should not be considered, on its own and without a physician’s input, as a definitive measure of the presence or severity of the disease.
Islam MS, Rahman W, Abdelkader A, Lee S, Yang PT, Purks JL, Adams JL, Schneider RB, Dorsey ER, Hoque E.
Using AI to measure Parkinson's disease severity at home.
NPJ Digit Med. 2023 Aug 23;6(1):156. doi: 10.1038/s41746-023-00905-9