The Warrior Watch Study found that subtle changes in a participant's heart rate variability (HRV) measured by an Apple Watch were able to signal the onset of COVID-19 up to seven days before the individual was diagnosed with the infection via nasal swab, and also to identify those who have symptoms.
"This study highlights the future of digital health," says the study's corresponding author Robert P. Hirten, MD, Assistant Professor of Medicine (Gastroenterology) at the Icahn School of Medicine at Mount Sinai, and member of the Hasso Plattner Institute for Digital Health at Mount Sinai and the Mount Sinai Clinical Intelligence Center (MSCIC). "It shows that we can use these technologies to better address evolving health needs, which will hopefully help us improve the management of disease. Our goal is to operationalize these platforms to improve the health of our patients and this study is a significant step in that direction. Developing a way to identify people who might be sick even before they know they are infected would be a breakthrough in the management of COVID-19."
The researchers enrolled several hundred health care workers throughout the Mount Sinai Health System in an ongoing digital study between April and September 2020. The participants wore Apple Watches and answered daily questions through a customized app. Changes in their HRV--a measure of nervous system function detected by the wearable device--were used to identify and predict whether the workers were infected with COVID-19 or had symptoms. Other daily symptoms that were collected included fever or chills, tiredness or weakness, body aches, dry cough, sneezing, runny nose, diarrhea, sore throat, headache, shortness of breath, loss of smell or taste, and itchy eyes.
Additionally, the researchers found that 7 to 14 days after diagnosis with COVID-19, the HRV pattern began to normalize and was no longer statistically different from the patterns of those who were not infected.
"This technology allows us not only to track and predict health outcomes, but also to intervene in a timely and remote manner, which is essential during a pandemic that requires people to stay apart," says the study's co-author Zahi Fayad, PhD, Director of the BioMedical Engineering and Imaging Institute, Co-Founder of the MSCIC, and the Lucy G. Moses Professor of Medical Imaging and Bioengineering at the Icahn School of Medicine at Mount Sinai.
The Warrior Watch Study draws on the collaborative effort of the Hasso Plattner Institute for Digital Health and the MSCIC, which represents a diverse group of data scientists, engineers, clinical physicians, and researchers across the Mount Sinai Health System who joined together in the spring of 2020 to combat COVID-19. The study will next take a closer look at biometrics including HRV, sleep disruption, and physical activity to better understand which health care workers are at risk of the psychological effects of the pandemic.
Hirten RP, Danieletto M, Tomalin L, Choi KH, Zweig M, Golden E, Kaur S, Helmus D, Biello A, Pyzik R, Charney A, Miotto R, Glicksberg BS, Levin M, Nabeel I, Aberg J, Reich D, Charney D, Bottinger EP, Keefer L, Suarez-Farinas M, Nadkarni GN, Fayad ZA.
Physiological Data from a Wearable Device Identifies SARS-CoV-2 Infection and Symptoms and Predicts COVID-19 Diagnosis: Observational Study.
Journal of Medical Internet Research, 2021. doi: 10.2196/26107
