Such simulations will involve modelling of drug interactions at the molecular and cellular level, will extend current technology to enable prediction of the effects of those interactions on the dynamics of the whole heart, and will lead to an understanding of how genetic factors can be used to assess patient-specific risk profiles. This requires a multi-level systems approach, based on multi-scale, multi-physics methods, including computations on adaptive spatial grids and multi-grid time integration. Computations on realistic models at appropriate spatial and temporal scales are currently not feasible, so we will investigate new algorithms and their implementation on high-performance platforms, including a new generation of petaflop computers, to achieve 'faster than real-time' simulation.
These tools form part of the infrastructure required to simulate the physiology of major organ systems, thereby contributing to the goal of creating the Virtual Physiological Human (VPH) [ICT-2007.5.3]. The balanced team in this project, including founders of the Human Physiome Project, has decades of experience in the experimental study and modelling of the electrophysiology and mechanics of the heart, while pharmaceutical industry partners bring deep understanding of the mechanisms of drug actions. The results will demonstrate the value of the VPH initiative to fundamental scientific understanding of the heart, with major economic and clinical impacts through accelerated drug development, approval and use.
For further information, please visit:
http://www.vph-predict.eu
Project co-ordinator:
The Chancellor, Master and Scholars of the University of Oxford
Partners:
- F. Hoffmann-La Roche AG
- Szegedi Tudományegyetem
- Fujitsu Laboratories of Europe Limited
- Glaxo Smithkline Research and Development
- Universidad Politécnica de Valencia
- Centro di Ricerca, Sviluppo e Studi Superiori in Sardegna
- Novartis Pharma AG
- Aureus Pharma SA
Timetable: from 06/2008 to 05/2011
Total cost: 5.545.692
EC funding: 4.100.000
Programme Acronym: FP7-ICT
Subprogramme Area: Virtual physiological human
Contract type: Collaborative project (generic)
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