Open Call HORIZON-JU-IHI-2022-01-01: An Innovative Decision-Support System for Improved Care Pathways for Patients with Neurodegenerative Diseases and Comorbidities

European Commission Neurodegenerative disorders represent a high societal burden impacting patients, their families, and public healthcare systems. Patients with a neurodegenerative disorder frequently display at least one comorbidity, which together with the observed polypharmacy creates a highly complex system that needs better understanding to optimise current care pathways. Recent developments give grounds for cautious optimism that a disease-modifying therapy is on the horizon. However, the high disease prevalence, and the complex evaluation process when such a therapy becomes available, will create challenges for already over-burdened healthcare systems. This will increase the demand for and importance of diagnostic and digital solutions that can drive the related clinical pathways and optimise and personalise care delivery.

The primary objective of this topic is to develop a decision-support system to enhance medical decisions with targeted clinical knowledge, patient information, and other health information for a more holistic (better integrating diagnosis, treatment and care and breaking silos across specialities) approach to managing and treating patients with a neurodegenerative disease and a comorbid condition, addressing the needs of today, while creating preparedness for a future paradigm-shift in treatment.

In their proposal, applicants should formulate how to best achieve all the outcomes/outputs of this topic, also describing the expected actual improvement in care and treatment outcomes and reflecting on aspects of implementation into routine care and sustainability, that are barriers to developing and distributing/delivering innovations. This should be preceded by a key stakeholder mapping to grasp the relevant players within this ecosystem and build and leverage as much as possible upon already available resources and learnings.

Proposals should address a patient population with a neurodegenerative disease where there is evidence of the importance of comorbidities in their healthcare pathways and on patient quality of life. The choice of the comorbidity should consider the burden for patients, carers and families, and the availability of medical technology-generated data. Cancer is out of scope.

Applicants should develop a (sustainable) re-usable, interoperable, and scalable digital platform, to safely and efficiently collect, curate, store, share, access, integrate and analyse multimodal longitudinal, dynamic health data generated within and outside the healthcare setting.

This will require breaking existing data silos across different medical specialities to allow the dynamic flow of information on the concomitant conditions and their interplay to improve the selection of the best possible care pathways, and patient adherence.

Data may include medical/laboratory data, automatically collected data, omics data, medical device data, treatment modality/intervention-type data, real-world evidence, including medical condition and lifestyle-related data collected via e-health solutions, smart devices, wearables, medical grade sensors and other patient self-reported data. Data on contextual information, for example on the socioeconomic environment as well as professional and informal caregivers (like availability, roles, interprofessional cooperation, interaction with the patient/client), the setting and organisation of care, staffing, and payment models, should be considered to enrich the dataset informing decision, as well as data from patient registries. Current European activities on digital health and care should be considered when relevant. The patient perspective and notably their quality of life, will need to be sufficiently considered including via patient-reported experiences and outcomes measurements (PREMs; PROMs). The perspective of families and carers should be also included.

Applicants should consider leveraging relevant large datasets that are already available at national and / or European level.

Ensuring data quality will be of paramount importance. In addition, applicants should ensure trustworthy and safe sharing of patient data through 'privacy and security by design'. They should also give ample consideration for the control of data reuse by patients and healthcare professionals, for example by the implementation of 'FAIR' data principles and a suitable data governance structure.

The platform should build on suitable existing platforms or elements thereof (for example specialised research infrastructures, including those developed by IMI projects) with proven efficiency and interoperability, complying with European privacy and security requirements and enabling integrated workflows of data management, curation, and analysis to amplify the intrinsic value of the datasets. Its design should allow for future expansion as well as continuous updates in a secure environment, plus potential integration with other platforms and easy adaptation for use in other health areas.

Advanced analytical and workflow tools (including artificial intelligence (AI)-based) and, where relevant, predictive simulations should be proposed which enable improved analysis of the integrated patient data in combination with clinical insights and expertise to optimise best practice guidelines, support better clinical decision-making and assessment of outcomes for optimised care pathways, bespoke to the patient and the healthcare system.

Applicants should also consider how the proposed solutions could be part of integrated community-based health and social services that optimise independence, quality of life and the wellbeing of the individual, including when relevant behavioural changes, while decreasing the burden on families and carers.

Applicants providing data as part of their applications should include in the proposals evidence that all legal, ethical, and intellectual property permissions are in place to ensure the availability of the data to the consortium.

Opening date: 28 June 2022

Deadline: 20 September 2022 17:00:00 Brussels time

Deadline Model: single-stage

Type of action: HORIZON-JU-RIA HORIZON JU Research and Innovation Actions

For topic conditions, documents and submission service, please visit:
https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/topic-details/horizon-ju-ihi-2022-01-01

Most Popular Now

Applications Open for SpinLab Accelerato…

The start-up accelerator supports entrepreneurial and innovative teams that want to grow sustainably and successfully scale their business model. With a strong hands-on mentality and a lot of passion, the...

Bayer to Accelerate Drug Discovery with …

Bayer AG and Google Cloud today announced a collaboration to drive early drug discovery that will apply Google Cloud's Tensor Processing Units (TPUs), which are custom-developed accelerators designed to run...

Allscripts Announces Corporate Name Chan…

Allscripts Healthcare Solutions, Inc. announced that, effective January 1, 2023, it has changed its name to Veradigm Inc. (NASDAQ: MDRX). Allscripts had been transitioning its solutions to the Veradigm brand...

220M€ Investment in Testing and Experime…

To make the EU the place where AI excellence thrives from the lab to the market, the European Union is setting up world-class Testing and Experimentation Facilities (TEFs) for AI. Together...

AI Tool Developed to Predict Risk of Lun…

Lung cancer is the leading cause of cancer death in the United States and around the world. Low-dose chest computed tomography (LDCT) is recommended to screen people between 50 and...

Bayer Acquires Blackford Analysis Ltd. B…

Bayer announced the acquisition of the global strategic imaging AI platform and solutions provider Blackford Analysis Ltd. The acquisition is part of Bayer's strategy to drive innovation in radiology, including...

Artificial Nerve Cells - Almost Like Bio…

Researchers at Linköping University (LiU), Sweden, have created an artificial organic neuron that closely mimics the characteristics of biological nerve cells. This artificial neuron can stimulate natural nerves, making it...

Veradigm Announces Strategic Investment …

Veradigm Inc. (NASDAQ: MDRX), formerly Allscripts Healthcare Solutions, Inc., announced an investment in Holmusk, a global behavioral health real-world evidence and data analytics company, as part of Holmusk's $45 million...

For Shared Decision-Making, Telemedicine…

Telemedicine may be just as effective as in-person visits when it comes to shared decision-making and communication for patients undergoing a first-time surgery consultation, according to a study published as...

A Blood Test for Cancer Shows Promise Th…

A team of researchers at the University of Wisconsin­-Madison has successfully combined genomics with machine learning in the quest to develop accessible tests that allow earlier detection of cancer. For many...

Open Call HORIZON-HLTH-2023-STAYHLTH-01:…

This topic aims at supporting activities that are enabling or contributing to one or several impacts of destination 1 "Staying healthy in a rapidly changing society". To that end, proposals...

Biomedical Institutions Agree on a Set o…

Eighty stakeholders from twenty major biomedical research institutions across the globe have agreed upon a list of 19 open science practices to be implemented and monitored. The study, led by...