Open Call SC1-PM-16-2017: In-Silico Trials for Developing and Assessing Biomedical Products

European Commission Proposals will develop innovative in-silico trials for designing, developing and assessing drugs, radiation and other biomedical and bioactive products. They will build on comprehensive biological and biomedical knowledge management and advanced modelling paradigms in order to be able to simulate the individual human physiology and physiopathology at the biological levels relevant for the biomedical product under study (at the cell level, tissue level or organism level) and the interaction with the product, thus taking into account the variability among individuals (for example, molecular pathways, cellular microenvironments, microbiota, genetics, gender characteristics, behaviours, comorbidities, development, diet). Virtual populations of individual patients will be built for simple or composite diseases, for example, from the patient-specific models by variations of different parameters and will allow simulating the action of the products and predicting the treatments outcomes in order to develop a personalised medicine approach. The proposed in-silico trials will be the result of a multidisciplinary effort (e.g. within the fields of computational modelling, systems biology, tissue mechanics, biology, pharmaceutics, medicine) and will also explore and inform of the reasons of fails and suggest improvements. To help establishing such computer simulated trials, measures for validation (human trials, animal studies, validation in cell cultures) of the in-silico models shall also be included in the proposed projects. The benefit for human health, environment and animal welfare should be analysed and quantified. Contact with regulators and consideration of the regulatory framework issues are highly recommended.

The Commission considers that proposals requesting a contribution from the EU of between EUR 4 and 6 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.

Planned opening date: 08 November 2016

Deadline Date: 14 March 2017 17:00:00

Type of action: RIA Research and Innovation action.

For topic conditions, documents and submission service, please visit:
https://ec.europa.eu/research/participants/portal/desktop/en/opportunities/h2020/topics/3062-sc1-pm-16-2017.html

PS: Find your partners or consortia preparing a project proposal
If you are working on Horizon 2020 research project proposals and you would be interested in a SME partner from Germany, please contact us, we are ready to share our experience, expertise and knowledge. If you need help to identify a potential partner with particular competences, facilities or experience, please explore and join our project, (HEALTH IT) SPACE, at www.healthitspace.eu.

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