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LLM-Based Detection of Depression Using WhatsApp Voice Notes

A new medical large language model (LLM) achieved over 91 percent accuracy in identifying female participants diagnosed with major depressive disorder after analyzing a short WhatsApp audio recording where participants described their week, according to a study published in the open-access journal PLOS Mental Health by Victor H. O. Otani, from Santa Casa de São Paulo School of Medical Sciences and Infinity Doctors Inc., Brazil, and colleagues.

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Video-Based Non-Contact Cardiopulmonary Coupling Analysis

From a physiological perspective, heartbeats and breathing do not operate independently in the human body. Cardiac rhythm varies with the respiratory cycle, and the close interaction between the two is known as cardiopulmonary coupling (CPC). CPC reflects the regulatory state of the autonomic nervous system and serves as an important physiological indicator for evaluating sleep quality, cardiovascular health, and stress levels.

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DiaCardia: Scalable and Accessible ECG-Based Prediabetes Screening, Anytime, Anywhere

DiaCardia, a novel artificial intelligence model that can accurately identify individuals with prediabetes using either 12-lead or single-lead electrocardiogram (ECG) data, has been recently developed. This breakthrough holds promise for future home-based prediabetes screening using consumer wearable devices, without requiring invasive blood tests. This study emphasizes the utility of the ECG as a powerful biomarker and highlights that the innovative AI model can contribute to the prevention of diabetes.

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BioPathNet: New AI Uncovers Hidden Patterns in Biomedical Knowledge Graphs

A new artificial intelligence (AI) method called BioPathNet helps researchers systematically search large biological data networks for hidden connections - from gene functions and disease mechanisms to potential therapeutic approaches. BioPathNet was developed by teams at Helmholtz Munich and Mila - Quebec Artificial Intelligence Institute in Montreal, Canada. The researchers are now presenting the method in the journal Nature Biomedical Engineering.

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Merck Launches ChemiSphere® App to Simplify Digital Data Access and Boost Lab Efficiency

Merck, a leading science and technology company, announced the launch of the ChemiSphere® app, a digital tool that allows scientists to instantly access product documentation and quality information via 2D barcodes on the Life Science products offered by Merck. The app is powered by the company’s secure digital traceability platform M-Trust™ and is designed to make data retrieval faster and more reliable, helping labs reduce manual steps and improve data integrity.

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Autonomous AI Agents Developed to Detect Early Signs of Cognitive Decline

A team of Mass General Brigham researchers has developed one of the first fully autonomous artificial intelligence (AI) systems capable of screening for cognitive impairment using routine clinical documentation. The system, which requires no human intervention or prompting after deployment, achieved 98% specificity in real-world validation testing. Results are published in npj Digital Medicine.

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Siemens Healthineers Co-Leads EU Alzheimer's Disease Care Initiative

Siemens Healthineers is to co-lead a major EU research initiative dedicated to improving the diagnosis, treatment and monitoring of Alzheimer’s Disease (AD). The project, ACCESS-AD, aims to create a collaborative, patient-centered strategy for Alzheimer’s care across Europe. It begins in January 2026 and unites more than 30 European partners from hospitals, universities, patient organizations, and industry, representing expertise in neurology, imaging, data science, and patient advocacy.

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Scientists Demonstrate First-Time Use of AI for Genetic Circuit Design

There are hundreds of cell types in the human body, each with a specific role spelled out in their DNA. In theory, all it takes for cells to behave in desired ways - for example, getting them to produce a therapeutic molecule or assemble into a tissue graft - is the right DNA sequence. The problem is figuring out what DNA sequence codes for which behavior.

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Highland Advisory Board Discussion: The Single Patient Record

A new attempt to create a national, longitudinal health record was one of the big ideas in the 10 Year Health Plan. However, the use case and architecture is far from clear, and there are some big commercial issues to address with health tech vendors...

The NHS has a troubled history when it comes to national record and data projects.

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AI Tools Speed Development of Antibody Probes to See Activity Inside Living Cells

Researchers at Colorado State University have determined how to use artificial intelligence (AI) to modify antibodies so they act as lightbulbs, enabling scientists to better see inside living cells to track errors in gene expression that can lead to cancer and other disorders.

The findings, published in Science Advances, outline an approach that is significantly faster than existing manual testing and development methods to address an ongoing challenge to see activity in tiny cells continuously and clearly.

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